Statins: Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins

Figure 2

Statins reduce cholesterol, and isoprenoids synthesis. The statins inhibit HMG-CoA-R and block the synthesis of mevalonate, cholesterol, and isoprenoids. In the hepatocyte, the reduction in cholesterol synthesis determines a reduction in VLDL synthesis and increase in the synthesis of LDL-R; thus, the reduced production of VLDL, IDL, and LDL and increased elimination of circulating IDL, and LDL, explain the reduction in LDL concentration. In the endothelial cells the reduction in the synthesis of isoprenoids determines a reduction of the inflammatory response mediated by inactivation of smgs from different families (Rho, Ras, Rab).