Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension

Table 1

Functions associated with ligand activation of the AT₁, AT₂, and Mas receptors.

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AT₁ receptor subtype

 Vasoconstriction

 Aldosterone release

 Vasopressin release

 Cardiac hypertrophy

 Fibrosis

 Proliferation

 Inflammation

 Platelet aggregation

 Oxidative stress

 Endothelial disruption

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AT₂ receptor subtype

 Vasodilation

 Antifibrotic

 Antiproliferative

 Antihypertrophic

 Antithrombotic

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Mas receptor

 Vasodilation

 Antifibrotic

 Antihypertrophic

 Antithrombotic

 Promotes endothelial function

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