New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
Figure 2
Effects of Ang II and Losartan on arterial blood pressure of rats chronically treated with XNT. The responses to increasing doses of Ang II were similar in vehicle- and XNT-treated (a) normotensive (Wistar-Kyoto rats—WKY) and (b) hypertensive (spontaneously hypertensive rats—SHR) rats. Likewise, the response to Losartan (0.25 mg/kg) was similar in vehicle- and XNT-treated (c) normotensive (WKY) and (d) hypertensive (SHRs) rats. The blood pressure was measured through a catheter inserted into the carotid artery and Ang II and Losartan were administrated in bolus using the jugular vein.
