New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
Figure 3
Schematic diagram showing the therapeutic strategies to modulate the activity of the renin-angiotensin system (RAS). In addition to the classical RAS blockers, that is, ACE inhibitors and AT1 receptor blockers, the figure highlights the renin inhibitors, the Ang-(1–7) formulations [HPβCD/Ang-(1-7) and cyclic Ang-(1-7)], the synthetic Mas receptor agonists (AVE 0991 and CGEN-856S), and the ACE2 activator (XNT). ACE: angiotensin-converting enzyme; AT1: Ang II type 1 receptor; AT2: Ang II type 2 receptor; Mas: Ang-(1–7) receptor; NEP: neutral-endopeptidase 24.11.
