International Journal of Hypertension / 2012 / Article / Tab 2

Research Article

Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension

Table 2

Genotype and allele frequencies.

MarkerGenotype frequenciesAllele frequencies

MTHFR C677TCCCTTTTotalCTTotal

Case170 (45.1%)174 (46.2%)33 (8.7%)377514 (68.2%)240 (31.8%)754
Control175 (44.5%)183 (46.6%)35 (8.9%)393533 (67.8%)253 (32.2%)786
Test statistic = 0.03, P = 0.99 ( ) = 0.02, P = 0.88 ( )

MTHFR A1298CAAACCCTotalACTotal

Case165 (44.8%)151 (41.0%)52 (14.2%)368481 (65.4%)255 (34.6%)736
Control162 (42.0%)173 (44.8%)51 (13.2%)386497 (64.4%)275 (35.6%)772
Test statistic = 1.10, P = 0.58 ( ) = 0.16, P = 0.69 ( )

MTRR A66GAAAGGGTotalAGTotal

Case103 (28.6%)192 (53.3%)65 (18.1%)360398 (55.3%)322 (44.7%)720
Control95 (26.5%)189 (52.8%)74 (20.7%)358379 (52.9%)337 (47.1%)716
Test statistic = 0.92, P = 0.63 ( ) = 0.79, P = 0.37 ( )

MTHFD1 G1958AGGAGAATotalGATotal

Case119 (32.7%)168 (46.2%)77 (21.1%)364406 (55.8%)322 (44.2%)728
Control104 (28.9%)183 (50.8%)73 (20.3%)360391 (54.3%)329 (45.7%)720
Test statistic = 1.73, P = 0.42 ( ) = 0.31, P = 0.58 ( )

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