International Journal of Hypertension / 2012 / Article / Tab 3

Research Article

Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension

Table 3

Genotype and allele frequencies, analysed by gender.

MarkerGenotype frequenciesAllele frequencies

MTHFR C677TCCCTTTTotalCTTotal

MaleCase76 (46.1%)75 (45.5%)14 (8.5%)165227 (68.8%)103 (31.2%)330
Control73 (39.9%)93 (50.8%)17 (9.3%)183239 (65.3%)127 (34.7%)366
Test statistic
= 1.35, P = 0.51 ( ) = 0.95, P = 0.33 ( )
FemaleCase94 (44.3%)99 (46.7%)19 (9%)212287 (67.7%)137 (32.3%)424
Control102 (48.6%)90 (42.9%)18 (8.6%)210294 (70%)126 (30%)420
Test statistic = 0.77, P = 0.68 ( ) = 0.53, P = 0.47 ( )

MTHFR A1298CAAACCCTotalACTotal

MaleCase77 (45.8%)68 (40.5%)23 (13.7%)168222 (66.1%)114 (33.9%)336
Control86 (47.5%)75 (41.4%)20 (11%)181247 (68.2%)115 (31.8%)362
Test statistic = 0.57, P = 0.75 ( ) = 0.37, P = 0.54 ( )
FemaleCase88 (44%)83 (41.5%)29 (14.5%)200259 (64.8%)141 (35.3%)400
Control76 (37.1%)98 (47.8%)31 (15.1%)205250 (61%)160 (39%)410
Test statistic = 2.13, P = 0.35 ( ) = 1.24, P = 0.27 ( )

MTRR A66GAAAGGGTotalAGTotal

MaleCase45 (28.1%)81 (50.6%)34 (21.3%)160171 (53.4%)149 (46.6%)320
Control40 (24.2%)92 (55.8%)33 (20%)165172 (52.1%)158 (47.9%)330
Test statisticχ 2 = 0.93, P = 0.63 ( ) = 0.11, P = 0.74 ( )
FemaleCase58 (29%)111 (55.5%)31 (15.5%)200227 (56.8%)173 (43.3%)400
Control55 (28.5%)97 (50.3%)41 (21.2%)193207 (53.6%)179 (46.4%)386
Test statistic = 2.29, P = 0.32 ( ) = 0.77, P = 0.38 ( )

MTHFD1 G1958AGGAGAATotalGATotal

MaleCase59 (36.9%)67 (41.9%)34 (21.3%)160185 (57.8%)135 (42.2%)320
Control48 (28.4%)89 (52.7%)32 (18.9%)169185 (54.7%)153 (45.3%)338
Test statistic = 4.05, P = 0.13 ( ) = 0.63, P = 0.43 ( )
FemaleCase60 (29.4%)101 (49.5%)43 (21.1%)204221 (54.2%)187 (45.8%)408
Control56 (29.3%)94 (49.2%)41 (21.5%)191206 (53.9%)176 (46.1%)382
Test statistic = 0.01, P = 0.99 ( ) = 0.00, P = 0.95 ( )

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.