International Journal of Hypertension / 2012 / Article / Fig 2

Research Article

Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

Figure 2

Effect of Ang (1-7) (15 pmol/kg/min; 4-hour infusion depicted by full line), antagonist, candesartan (0.1 mg/kg bolus IV; depicted by an arrow), Ang (1-7) + candesartan, and Ang (1-7) + candesartan + antagonist, PD123319 (50 μg/kg/min for 2 hours; depicted by dashed line), on MAP in (a) adult WKY rats ( ) and (b) aged WKY rats ( ). Values represent mean ± SEM. * ; ** ; *** , for treatment effect of Ang (1-7) + candesartan versus all other treatments as indicated (2-way RM ANOVA).
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