Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats
Schema depicting differential mechanisms of Ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. expression was similar in aortae from adult and aged rats whereas there was upregulation of , MasR, and ACE2. Therefore, a lower level of blockade with candesartan (X) was required in aged animals (b) compared with adult animals (a) in order to unmask the vasodilator axis. MasR was not functionally active in adult rats.