International Journal of Hypertension / 2012 / Article / Tab 1

Research Article

Differential Mechanisms of Ang (1-7)-Mediated Vasodepressor Effect in Adult and Aged Candesartan-Treated Rats

Table 1

Resting MAP recorded on separate days before drug treatments, as indicated.

TreatmentMAP (mmHg)

Group 1 ( )
 Saline132 ± 14
 Ang-(1-7) (15 pmol/kg/min)124 ± 4
 Candesartan (0.01 mg/kg)131 ± 6
 Ang-(1-7) and candesartan134 ± 4

Group 2 ( )
 Saline131 ± 13
 Ang-(1-7) (15 pmol/kg/min)136 ± 13
 Candesartan (0.01 mg/kg)126 ± 15
 Ang-(1-7) and candesartan136 ± 16

Group 3 ( )
 Ang-(1-7) (15 pmol/kg/min)138 ± 8
 Candesartan (0.1 mg/kg)135 ± 8
 Ang-(1-7) and candesartan139 ± 11
 Ang-(1-7), candesartan, and PD123319 (50 μg/kg/min)139 ± 5

Group 4 ( )
 Ang-(1-7) (15 pmol/kg/min)143 ± 10
 Candesartan (0.1 mg/kg)142 ± 10
 Ang-(1-7) and candesartan142 ± 9
 Ang-(1-7), candesartan, and PD123319 (50 μg/kg/min)137 ± 9

Group 5 ( )
 Ang-(1-7) (15 pmol/kg/min)128 ± 11
 Candesartan (0.1 mg/kg)122 ± 10
 Ang-(1-7) and candesartan133 ± 5
 Ang-(1-7), candesartan, and A779 (15 pmol/kg/min)132 ± 2

Group 6 ( )
 Ang-(1-7) (15 pmol/kg/min)129 ± 5
 Candesartan (0.01 mg/kg)126 ± 10
 Ang-(1-7) and candesartan132 ± 6
 Ang-(1-7), candesartan, and A779 (15 pmol/kg/min)125 ± 8

Values are ± SEM.