Clinical Study

Role of HO/CO in the Control of Peripheral Circulation in Humans

Figure 1

Effect of heme oxygenase inhibition with stannous mesoporphyrin IX (SnMP) (200 μM), of nitric oxide synthase inhibition with L-NG-Nitroarginine methyl ester (L-NAME) (100 μM), and of both, on skin blood flow measured by laser Doppler flowmetry. SnMP and L-NAME were administered locally by iontophoresis. *P versus baseline; **P versus L-NAME.
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