Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="1"><hr/></td></tr><tr><td align="left">(i) AT-1 receptor blocker </td></tr><tr><td align="left">(ii) Mineralocorticoid receptor blocker </td></tr><tr><td align="left">(iii) Aldosterone synthase inhibitor</td></tr><tr><td align="left">(iv) Epithelial sodium channel (ENaC) blocker</td></tr><tr><td align="left">(v) Antidigitalis blocking antibody</td></tr><tr><td align="left">(vi) Anti-oxidative agent</td></tr><tr class="table-tr"><td colspan="1"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Intracranial pretreatments with one of these agents blunt pressor responses caused by centrally administered sodium, sodium-induced hypertension in Dahl salt-sensitive rats, hypertension caused by subcutaneously injected angiotensin II, or aldosterone.

International Journal of Hypertension

tab1

Table 1

Table 1: Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension 

Table 1 | Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension 