Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin
Figure 3
HO-1 induction, CO, and Bilirubin attenuate hypoxia-induced sFlt-1 secretion. In response to hypoxic incubation, placental explants demonstrate a significant increase in the production of sFlt-1 when compared to normoxic controls. Administration of CoPP significantly attenuated sFlt-1 released under both normoxic and hypoxic conditions. Bilirubin, while having no effect under normoxic conditions, slightly but significantly decreased sFlt-1 release when compared to hypoxic controls. Administration of a CO-releasing molecule (CORM) again had no effect under normoxic conditions but significantly attenuated sFlt-1 release in hypoxic explants. Statistical significance at the level is indicated by “*” versus normoxic controls and “#” versus hypoxic controls.
