Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes

Figure 1

Schematic representation of the enzymatic pathways involved in the generation of Ang-(1-7). Ang-(1-7) can be formed by at least three different pathways: directly from Ang I by NEP and PEP, by hydrolysis of Ang II by ACE2, PEP, and PCP, and finally by hydrolysis of Ang-(1-9) by ACE and NEP. ACE, ACE2, and NEP are found in cardiomyocytes.