Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes
Figure 2
Schematic illustration of ACE2 modulation in cardiomyocytes by different molecules. Ang II, and ET-1 through MAPKK1 activation, and aldosterone lead to ACE2 mRNA downregulation. To date no reported effects of Ang-(1-7) on ACE2 levels have been demonstrated, although this peptide is capable of antagonizing Ang II and ET-1 effects on ACE2 mRNA. Conditions that favor ACE2 downregulation would likely lead to more deleterious effects during cardiovascular disease development.ā= activation; - -= inhibition; ET-1 = endothelin; Ang II = angiotensin II; Ang-(1-7) = angiotensin-(1-7); ET-R = endothelin receptor; AT1-R = AT1 receptor; Mas = Mas receptor; MR = mineralocorticoid receptor; MAPKK1 = mitogen-activated protein kinase kinase 1.
