The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction

Table 1

Weight, basic histological and cardiac parameters.

	Sham	MI	Sham	MI	MI
	saline	saline	high cAng-(1–7)	low cAng-(1–7)	high cAng-(1–7)
BW, g	477.1 ± 6.6	475.3 ± 6.4	484.6 ± 7.4	458.6 ± 10	492.3 ± 9.5
Infarct size, %	0 ± 0	15.853 ± 3.17	0 ± 0	9.721 ± 2.89	14.535 ± 4.10
Fibrosis, %	3.896 ± 0.57	3.992 ± 0.39	4.289 ± 0.54	4.695 ± 0.65	4.479 ± 0.34
HR beats/min	255.12 ± 16.0	260.3 ± 5.5	240.4 ± 9.8	274.7 ± 6.2	266.7 ± 6.2
MaxP, mmHg	107.8 ± 3.8	103.5 ± 2.9	98.6 ± 8.3	93.0 ± 4.7	96.4 ± 4.7
ESPress, mmHg	103.6 ± 4.2	100.1 ± 3.0	93.5 ± 9.3	89.4 ± 5.3	92.4 ± 5.1
dpdtMax, mmHg/sec	5572.0 ± 188.2	5456.8 ± 198.7	5533.0 ± 530.7	5026 ± 269.3	5111.3 ± 345.1
dpdtMin, mmHg/sec	−5189.1 ± 178.8	−4919.1 ± 265.2	−6123.5 ± 1268.9	−4615.4 ± 361.8	−4742.6 ± 404.9
𝑁	8	25	5	12	12