Influence of Angiotensin II Subtype 2 Receptor (R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (R) Blockade
Figure 1
Radiotelemetry recordings of (a) MAP and (b) HR of adult SHRs, at baseline and during treatment with vehicle (control, ), candesartan cilexetil (2 mg/kg/day) alone () or in combination with PD123319 (10 mg/kg/day, ), or PD123319 alone. Analogous radiotelemetry recordings of (c) MAP and (d) HR of senescent SHRs, at baseline and during treatment with vehicle (control, ), candesartan cilexetil alone () or in combination with PD123319 (), PD123319 alone (), or hydralazine (30 mg/kg/day, ). ** versus control (2-way ANOVA).
