Influence of Angiotensin II Subtype 2 Receptor (R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (R) Blockade
Figure 4
Mean data of interstitial collagen volume fraction of (a) left and (b) right ventricles of adult SHRs treated with vehicle (control, ), candesartan cilexetil (2 mg/kg/day) alone () or in combination with PD123319 (10 mg/kg/day, ) or PD123319 alone. Interstitial collagen volume fraction of (c) left and (d) right ventricles of senescent SHRs treated with vehicle (control, ), candesartan cilexetil alone () or in combination with PD123319 (), PD123319 alone (), or hydralazine (30 mg/kg/day, ).
