Influence of Angiotensin II Subtype 2 Receptor (AT₂R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor (AT₁R) Blockade

Table 1

Effect of drug treatments on body weight, ventricular weight, and plasma Ang II of adult and senescent SHRs.

	Control	Candesartan cilexetil	Candesartan cilexetil + PD123319	PD123319	Hydralazine
Body weight (g)
Adult SHRs	411 ± 11	415 ± 5	410 ± 5	414 ± 3	—
Senescent SHRs	417 ± 9	427 ± 7	428 ± 10	399 ± 9	419 ± 11
Ventricular weight (mg)
Adult SHRs	1423 ± 23	1229 ± 39*	1207 ± 30*	1474 ± 48	—
Senescent SHRs	2114 ± 74	1796 ± 85*	1962 ± 86	2136 ± 163	1952 ± 49
Plasma Ang II (pg/mL)
Adult SHRs	220 ± 100	1597 ± 234*	2785 ± 817*	68 ± 18	—
Senescent SHRs	80 ± 10	383 ± 89*	271 ± 51*	64 ± 23	91 ± 16

Values are mean ± SEM. *𝑃<0.05 versus age-matched control (1-way ANOVA).