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International Journal of Hypertension
Volume 2012 (2012), Article ID 590683, 4 pages
Review Article

Antihypertensive Treatment in the Elderly and Very Elderly: Always “the Lower, the Better?”

1Department of Internal Medicine, “Santa Maria della Misericordia” Hospital, 45100 Rovigo, Italy
2Department of Neuroscience, “Santa Maria della Misericordia” Hospital, 45100 Rovigo, Italy
3Department of Nuclear Medicine, “Santa Maria della Misericordia” Hospital, 45100 Rovigo, Italy
4Department of Clinical and Experimental Medicine, University of Padua, 35128 Padua, Italy

Received 14 July 2011; Accepted 25 July 2011

Academic Editor: Blas Gil Extremera

Copyright © 2012 Alberto Mazza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Arterial hypertension (HT) is age dependent and, with the prolongation of life expectancy, affects more and more elderly people. In the elderly, HT is a risk factor for organ damage and cardiovascular (CV) events. Both pharmacologic and nonpharmacologic reduction of blood pressure (BP) is associated with a corresponding decrease in systolic-diastolic or isolated systolic HT. Clinical trials have shown that BP lowering is associated with a decrease in stroke and other CV events. Therefore, BP reduction per se appears more important than a particular class of antihypertensive drugs. The benefit of antihypertensive treatment has been confirmed up to the age of 80 years, remaining unclear in the octogenarians. The benefit in lowering diastolic BP between 80 and 90 mmHg is well established, while that of lowering systolic BP below 140 mmHg requires further confirmations.