Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Figure 1

Effect of HO-2 deletion on body weight and adiposity. Figures showing wild-type (WT), HO-2 null (HO-2^(−/−)) and L-4F treated HO-2^(−/−) mice (HO-2^(−/−) + L-4F) after 6 weeks of treatment. (a) Effect of L-4F on body weight on HO-2^(−/−) mice. (b) Effect of L-4F on subcutaneous body weight on HO-2^(−/−) mice. (c) Effect of L-4F on visceral body weight on HO-2^(−/−) mice. Results are means ± SE, 𝑛=6, *𝑃<0.05 versus WT; ^#𝑃<0.05 versus HO-2^(−/−).

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