Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Figure 2

Effect of L-4F on blood glucose, blood pressure, insulin sensitivity, and glucose tolerance in HO-2 null mice. (a) Blood glucose. Values are means ± SE, 𝑛=6,^∗𝑃<0.05 versus WT; ^#𝑃<0.05 versus HO-2^(−/−). (b) Blood pressure values are means ± SE, 𝑛=6,^∗𝑃<0.05 versus respective WT, ^#𝑃<0.05 versus respective HO-2^(−/−). HO-2^(−/−). (c) Intraperitoneal insulin sensitivity (IPITT) and glucose tolerance (IPGTT) (d) tests were performed as described in research designs and methods. Results are means ± SE, 𝑛=6. (IPITT) *𝑃<0.05 versus WT, ^#𝑃<0.05 versus HO-2^(−/−), (IPGTT). *𝑃<0.05 versus WT, ^#𝑃<0.05 versus HO-2^(−/−).

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