Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Figure 5

Schematic, the upregulation of HO-1 and adiponectin levels by L-4F coincides with increased pAMPK and LKBI levels providing a signaling mechanism by which L-4F rescues the metabolic phenotype and improves vascular function.