Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion

Table 1

Effects of DALA (80 μmol/kg, IV), biliverdin (20 mg/Kg, IV), and bilirubin (30 mg/Kg, IV) administration on heart rate (HR), mean arterial pressure (MAP), renal blood flow (RBF), and calculated renal vascular resistance (RVR).

		HR	MAP	RBF	RVR
	𝑁	(bpm)	(mmHg)	(ml/min)	(mmHg/ml/min)
No pretreatment
Control		385±0.13	110±0.06	5.6±0.12	19.6±0.14
Vehicle	8	395±0.16	114±0.08	5.8±0.14	19.7±0.11
DALA	8	382±0.12	118±0.09	5.9±0.16	20.0±0.18
Biliverdin	8	396±0.25	113±0.04	6.1±0.15	18.6±0.21
Bilirubin	8	398±0.18	109±0.15	5.4±0.14	20.1±0.24
Chronic L-NAME
Control		398±0.19	153±0.05	5.5±0.14	27.8±0.28
Vehicle	8	400±0.23	150±0.12	5.2±0.18	28.8±0.20
DALA	8	403±0.14	155±0.24	5.8±0.21	28.2±0.38
Biliverdin	8	396±0.19	158±0.15	5.5±0.14	28.7±0.47
Bilirubin	8	399±0.24	152±0.05	5.1±0.14	29.2±0.32