Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice

Figure 3

Bone marrow deficiency of ACE2 augments glucose intolerance at specific time points following glucose injection in HF-fed C57BL/6 mice. (a) Glucose tolerance tests (GTT) in HF-fed chimeric mice transplanted with bone marrow from Ace2^+/y or ^−/y mice. (b) Percent glycosylated hemoglobin levels and plasma insulin concentrations (c) in Ace2^+/y and ^−/y chimeric mice. Data are mean ± SEM from 𝑁=8–15mice/donor genotype. *: 𝑃<0.05 compared to Ace2^+/y.

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