Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults

Table 2

Hypertension-related gene polymorphisms and serum NT-proBNP, plasma aldosterone, and urinary 8-OHdG concentration.

	NT-proBNP (pg/mL)
ACE	II	DI	DD
	46.3±4.0 (42)	57.1±5.8 (43)	46.0±9.6 (12)
AGT A-6G	AA	AG/GG
	50.7±4.5 (61)	49.2±5.1 (32)
AGT M236T	MM/MT		TT
	48.1±5.2 (29)		47.8±4.6 (52)
AGTR1 A1166C	AA	AC/CC
	48.4±3.4 (75)	45.4±17.8 (7)
CYP11B2 C-344T	CC	CT	TT
	48.7±4.9 (46)	51.7±5.1 (39)	56.6±13.5 (9)
PAI-1	5G5G	4G5G	4G4G
	35.5±4.5 (11)	57.2±5.0 (44)	49.0±5.5 (40)
	Aldosterone (pg/mL)
GRK4	0	1	2≦
	91.1±7.4 (26)	80.2±5.4 (40)	88.4±8.0 (23)
ACE	II	DI	DD
	91.6±6.3 (41)	75.7±4.5 (43)	89.9±10.4 (11)
AGT A-6G	AA	AG/GG
	77.8±3.9 (61)	92.2±7.3 (32)
AGT M236T	MM/MT		TT
	77.5±5.5 (29)		84.5±5.1 (52)
AGTR1 A1166C	AA	AC/CC
	82.5±4.1 (75)	78.2±9.6 (7)
CYP11B2 C-344T	CC	CT	TT
	76.7±4.6 (46)	88.1±5.9 (39)	92.9±12.9 (9)
PAI-1	5G5G	4G5G	4G4G
	86.9±11.2 (11)	85.8±5.8 (44)	78.3±4.6 (40)
	8-OHdG (ng/mL/g/crea)
GRK4	0	1	2≦
	107.5±5.0 (23)	95.8±4.2 (39)	101.0±5.0 (23)
ACE	II	DI	DD
	106.7±4.2 (38)	98.7±3.5 (43)	91.2±7.7 (12)
AGT A-6G	AA	AG/GG
	97.6±2.9 (59)	105.3±5.2 (31)
AGT M236T	MM/MT		TT
	103.7±5.5 (28)		98.3±3.1 (50)
AGTR1 A1166C	AA	AC/CC
	100.7±3.0 (72)	93.9±5.8 (7)
CYP11B2 C-344T	CC	CT	TT
	102.7±3.7 (44)	100.1±4.4 (39)	91.5±4.5 (8)
PAI-1	5G5G	4G5G	4G4G
	88.1±8.5 (9)	102.2±3.9 (43)	102.2±3.9 (39)

Number of subjects in each group is indicated in parenthesis below the genotype. GRK4: G-protein coupled receptor kinase 4, ACE: Angiotensin converting enzyme, AGT: angiotensinogen, AGTR1: Angiotensin II type 1 receptor, CYP11B2: aldosterone synthase, PAI-1: plasminogen activator inhibitor-1, 8-OHdG: 8-hydroxy-2′-deoxyguanosine. Data are represented by mean ± SE. Cochran-cox test was used for the paired comparison and one-way factorial ANOVA was applied for multiple comparisons.