Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury
Figure 2
Effects of the treatment with AVE0991 in histological injury in a model of renal ischemia and reperfusion in mice. AVE0991 (AVE, 9.0 mg/kg) or vehicle (VE; 10 mM KOH in 0.9% NaCl) was given immediately after ischemia and 12 h after reperfusion. All analyses were performed at 24 h after reperfusion. Representative photomicrographs show H&E-stained sections from sham-operated animals (CT, a, b) and animals subjected to I/R, which were treated with vehicle (VE, c, d) and AVE0991 (AVE, 9 mg/kg, e, f). There was severe renal damage with vacuolization of tubular epithelium (c) (insert) and tubular dilation and protein casts (arrow) and extensive tubular necrosis (d) in mice subjected to I/R. Original magnification: ×600. Index of glomerular injury (g) and index of tubulointerstitial injury (h) were graded in a blind manner, as described in Material and Methods. Symbols represent results in single animals, and the trace is median value for all animals. * when compared with VE-treated group; # when compared with CT.
