Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury

Table 1

Effect of renal ischemia and reperfusion on renal function parameters, local CXCL1 production, and local and remote neutrophil accumulation. Urinary creatinine (mg/dL), serum creatinine (mg/dL), serum osmolality (mOsm/Kg H₂O), urinary osmolality (mOsm/Kg H₂O), serum CXCL1 (pl/mL serum), and renal and pulmonary neutrophils (relative units).

	Control	I/R	𝑛	𝑃
Urinary creatinine (mg/dL)	700±5.1	170±1.2 *	6	0.001
Serum creatinine (mg/dL)	0.29±0.1	5.34±1.2 *	4	0.016
Serum osmolality (mOsm/Kg H2O)	317±10.4	360±17.8 *	6	0.006
Urinary osmolality (mOsm/Kg H2O)	3996±340	905±69 *	6	0.06
Serum CXCL1/KC (pg/mL)	94±70	940±164 *	6	0.008
Renal neutrophils (relative units)	0.26±0.13	5.3±1.2 *	4	0.016
Lung neutrophils (relative Units)	2.2±0.5	5.6±0.5 *	5	0.0015