Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population

Table 2

FBAT analysis for blood pressure-related traits in quilombos.

Gene	Variant	rs	F		Phenotypes
					EH	SBP	DBP
ACE	I/D	rs1799752	0.50	NIF	97	93	95
				P value	0.774	0.155	0.123
NOS3	Glu298Asp	rs1799983	0.16	NIF	63	63	61
				P value	0.101	0.050	0.079
GNB3	C825T	rs5443	0.58	NIF	86	84	82
				P value	0.793	0.417	0.342
GNB3	G-350A	rs5441	0.68	NIF	79	76	76
				P value	0.063	0.672	0.565
AGT	M235T	rs699	0.27	NIF	96	92	94
				P value	0.608	0.293	0.579
ADD2	c.-154+20128C>A	rs3755351	0.34	NIF	97	93	95
				P value	0.196	0.209	0.137
GRK4	A486V	rs1801058	0.24	NIF	70	69	68
				P value	0.096	0.229	0.230

NIF: number of informative families. F: allele frequency for the risk allele. EH: essential hypertension. SBP: systolic blood pressure (mmHG). DBP: diastolic blood pressure (mmHg). All analyses were adjusted for covariates (age, gender, and BMI when appropriate). Similar results were obtained for other FBAT approaches (e.g. prevalence adjusted, mean centered, or minimal variance approaches) (data now shown). All results refer to analyses performed under assumption of an additive model of action. Qualitatively analogous results were observed for other genetic models (e.g., dominant and recessive) (data not shown).