Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population
Table 5
Genotype frequencies for the seven studied polymorphisms in normotensive and hypertensive quilombo subjects.
Gene/Status
Genotype, n (%)
P HWE
F
P MAX3
ACE (I/D)
I/I
I/D
D/D
Hypertensive
39 (21.91)
92 (51.69)
47 (26.40)
0.474
0.518
0.227
Normotensive
54 (26.21)
92 (44.66)
60 (29.13)
NOS3 (Glu298Asp)
Glu/Glu
Glu/Asp
Asp/Asp
Hypertensive
127 (71.35)
47 (26.40)
4 (2.25)
0.842
0.150
0.922
Normotensive
151 (73.30)
50 (24.27)
5 (2.43)
GNB3 (C825T)
C/C
C/T
T/T
Hypertensive
42 (23.60)
74 (41.57)
62 (34.83)
0.999
0.592
0.054
Normotensive
22 (10.68)
111 (53.88)
73 (35.44)
GNB3 (G-350A)
G/G
A/G
A/A
Hypertensive
93 (52.25)
60 (33.71)
25 (14.04)
0.028
0.297
0.595
Normotensive
106 (51.46)
82 (39.81)
18 (8.74)
AGT (M235T)
Thr/Thr
Thr/Met
Met/Met
Hypertensive
91 (51.12)
73 (41.01)
14 (7.87)
0.425
0.259
0.482
Normotensive
123 (59.71)
68 (33.01)
15 (7.28)
ADD2 (A/C)
A/A
A/C
C/C
Hypertensive
27 (15.17)
94 (45.63)
83 (46.63)
0.256
0.661
0.565
Normotensive
22 (10.68)
68 (38.20)
90 (43.69)
GRK4 (A486V)
Ala/Ala
Ala/Val
Val/Val
Hypertensive
98 (55.06)
72 (40.45)
8 (4.49)
0.893
0.253
0.586
Normotensive
117 (56.80)
72 (34.95)
17 (8.25)
HWE: Hardy-Weinberg equilibrium; F: frequency of the risk allele; MAX3: max-statistic; MAX3-based results are adjusted for age, gender, and BMI.
