Clinical Study
Effects of Telmisartan with Hydrochlorothiazide versus Valsartan with Hydrochlorothiazide in Patients with Moderate-to-Severe Hypertension
Table 2
Mean seated clinic trough BP and changes from baseline by treatment group.
| | T80/H25 () | V160/H25 () | Placebo () |
| | SBP, mm Hg | | | | | Baseline (SD) | 167.6 (5.4) | 168.3 (5.8) | 167.1 (5.9) | | End of study (SD) | 136.6 (15.3) | 139.75 (16.4) | 160.2 (14.9) | | Change from baseline (SD) | −31.1 (15.1) | −28.6 (15.9) | −7.0 (14.3) | | Adjusteda change from baseline (SE) | −31.1 (0.9) | −28.4 (0.9) | −7.3 (1.7) | | Comparison to T80/H25 (95% CI) | | −2.7 (−5.1, −0.3)
| −23.8 (−27.5, −20.0)
| | DBP, mm Hg | | | | | Baseline (SD) | 103.2 (4.4) | 103.4 (4.8) | 103.4 (4.1) | | End of study (SD) | 85.1 (9.4) | 87.3 (10.4) | 98.3 (10.1) | | Change from baseline (SD) | −18.1 (8.7) | −16.1 (9.3) | −5.0 (9.5) | | Adjusteda change from baseline (SE) | −18.3 (0.52) | −16.3 (0.5) | −5.3 (1.0) | | Comparison to T80/H25 (95% CI) | | −2.0 (−3.4, −0.6)
| −13.0 (−15.2, −10.8)
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BP: blood pressure; CI: confidence interval; DBP: diastolic blood pressure; SBP: systolic blood pressure; SD: standard deviation; SE: standard error; T80/H25: telmisartan 80 mg/hydrochlorothiazide 25 mg; V160/H25: valsartan 160 mg/hydrochlorothiazide 25 mg.
aAdjusted for effects of baseline, study, gender, and race.
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