International Journal of Hypertension / 2013 / Article / Tab 1

Review Article

Resistant Hypertension and Obstructive Sleep Apnea

Table 1

Effects of continuous positive airway pressure therapy on resistant hypertension.

StudyStudy design, populationSample size ( )InterventionResults

Logan et al., 2003 [6]Prospective observational, refractory HTN, AHI ≥ 1011 CPAP for 2 nights in sleep lab and then 2 months CPAP used BP acutely and over two months

Martinez -Garcia et al., 2007 [7]Prospective observational, difficult to treat HTN, AHI ≥ 1533 CPAP for 2 months CPAP systolic BP, particularly at night

Dernaika et al., 2009 [8]Retrospective chart review, observational, HTN, AHI > 598CPAP therapy for 1 year, controlled HTN ( 56) versus resistant HTN
( 42)
CPAP permitted deescalation of anti-HTN treatment in 71% of subjects with resistant HTN, no significant change in controlled HTN

Lozano et al., 2010 [9]Prospective randomized controlled parallel trial, resistant HTN, AHI ≥ 1575CPAP ( 38) versus conventional treatment ( 37) CPAP for 3 months led to in 24 hr ABP in patients who used CPAP > 5.8 hr/night

24 hr ABP: 24-hour ambulatory blood pressure monitoring, AHI: apnea hypopnea index, BP: blood pressure, CPAP: continuous positive airway pressure, HTN: hypertension.