DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin-Dependent Hypertensive Mice

Figure 3

Bone marrow mononuclear cell DNA damage assessed by the comet assay. The left bar graphs demonstrate the average DNA damage index (a) and frequency (b). **𝑃<0.01 versus the Sham group (Student’s 𝑡 test for independent samples). Fluorescent images (c) are typical comets demonstrating increased DNA fragmentation in a renovascular hypertensive (2K1C) mouse compared with a normotensive (Sham) mouse. The lines graph (c) demonstrates the average percentages of DNA damage percentages for each genotoxicity level, comparing the 2K1C (filled circles, 𝑛=5) with the Sham (empty circles, 𝑛=6) mice. **𝑃<0.01 versus the Sham group (two-way Anova). Values are the means ± SEM.

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