Clinical Implications of the Change in Glomerular Filtration Rate with Adrenergic Blockers in Patients with Morning Hypertension: The Japan Morning Surge-1 Study

Table 3

Factors associated with change in eGFR and UACR.

Variable	Change in eGFR (6th month minus baseline)		Change in UACR (6th month minus baseline)
	β coefficient	𝑃 value	β coefficient	𝑃 value
Use of doxazosin (use = 1, no use = 0)	−0.107	0.012	−0.178	<0.001
Change in morning systolic BP (6th month minus baseline)	0.085	0.045	0.251	<0.001
Adjusted 𝑅^2	0.101		0.117

Adjustments were made for body mass index, hyperlipidemia (Yes = 1; No = 0), diabetes mellitus (Yes = 1; No = 0), smoking habit (Yes = 1; No = 0), drinking habit (Yes = 1; No = 0), and change in morning systolic BP.
eGFR: estimated glomerular filtration rate. UACR: urinary albumin to creatinine ratio. BP: blood pressure. 𝑅²: determination coefficient.