Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model

Table 2

Oxidative stress and morphometric variables.

Variable	W	FFR	SHR	FFHR	FFHR + C	FFHR + T
NAD(P)H oxidase activity; (counts/min/mg tissue)	40.5 ± 6	133 ± 5*	160 ± 9.1^*#	297 ± 9.1^*#∧	142 ± 9.1^*∧**	97 ± 2.1^*∧**
Arterial eNOS activity; (dpm/mg/prot/min)	85.0 ± 2	60.1 ± 2.6*	80.0 ± 2.1	56.4 ± 5.7^*#∧	86.4 ± 1.1**	84.6 ± 1.1**
TBARS (𝜇mol/L)	1 ± 0.1	2.2 ± 0.1*	1.69 ± 0.1*	2.8 ± 0.1^*#∧	1.03 ± 0.6^#∧**	0.73 ± 0.4^#∧**
Relative heart weight; (mg/100 g body weight)	225 ± 4	290 ± 4*	330 ± 1.8^*#	400 ± 4^*#∧	262 ± 4**	289 ± 4**
Myocardiocyte area (𝜇m^2)	1682 ± 69	2066 ± 57*	2222 ± 78^*#	3242 ± 55^*#∧	1588 ± 55**	2188 ± 35**
Media/Lumen ratio mesenteric arteries	13.9 ± 0.3	10.2 ± 0.5*	8.9 ± 0.6^*#	8.45 ± 0.2^*#	14.5 ± 5**	9.5 ± 5**

The above values correspond to stress oxidative and morphometrics variables.
Symbols indicate: *𝑃<0.001 versus WKY; ^∧𝑃<0.001 versus SHR; ^#𝑃<0.01 versus FFR; **versus FFHR.