Inflammation and Hypertension: Are There Regional Differences?

Figure 1

Early programming inducing stressors lead to alterations in gene expression (such as methylation of DNA or modification of histones) on phenotype producing persistent influences on metabolism. The conflict between the earlier programming and the later presence of abdominal obesity may have produced a higher sensitivity of this population to develop a state of low degree inflammation, insulin resistance and, consequently, an epidemic of hypertension, diabetes, and CVD.