Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2013, Article ID 538017, 8 pages
Clinical Study

Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans

1Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USA
2Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, NY 10027, USA
3ECRI Institute, Health Technology Assessment Group, Plymouth Meeting, PA 19462, USA
4Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
5Department of Kinesiology, Missouri State University, Springfield, MO 65897, USA
6Department of Exercise Science, College of Education, Shippensburg University, Shippensburg, PA 17257, USA
7Vascular Health Laboratory, Department of Kinesiology & Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA
8Division of Cardiology, Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140, USA

Received 21 December 2012; Accepted 10 February 2013

Academic Editor: Nicolas Federico Renna

Copyright © 2013 Dianne M. Babbitt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing. Participants engaged in 6 months of AEXT. Following the AEXT intervention, all baseline tests were repeated. FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT. Changes in inflammatory biomarkers did not significantly predict the change in FMD. The change in significantly predicted the change in IL-10. Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans.