Essential Hypertension: An Approach to Its Etiology and Neurogenic Pathophysiology
Figure 3
Diagram of the central nervous system pathways that may be activated by an increase in one or more of the following agents: circulating , , circulating and . Left: agents, acting primarily on the sensorial SFO and OVLT, acutely activate a sympathoexcitatory angiotensinergic pathway that increases the activity of the presympathetic pPVN neurons. Right: chronic increase in these agents also activates, via the SFO and the OVLT, a neuromodulatory pathway, which then maintains enhanced excitatory angiotensinergic activity on the presympathetic pPVN neurons, leading to sustained sympathetic activation and hypertension. See further details in text. Diagram adapted from [10, 19–21].
