International Journal of Hypertension / 2013 / Article / Tab 3

Clinical Study

Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT

Table 3

Association of clinical outcomes with treatment resistant hypertension.

Clinical outcomesAfrican AmericanWhite
Number of events Event rates
per 1000 person-years
Odds ratio ( value) for cases versus controlsNumber of events Event rates
per 1000 person-years
Odds ratio ( value) for cases versus controls
TRH cases ( )Controls ( )TRH casesControlsUnadjustedAdjusted*TRH cases ( )Controls ( )TRH casesControlsUnadjustedAdjusted*

CHD
(fatal CHD or nonfatal MI)
822518.06.92.66 (<0.001)3.44 (<0.001)1597526.29.42.80 (<0.001)2.40 (<0.001)
Stroke43229.36.11.55 (0.10)1.15 (0.66)642710.33.43.04 (<0.001)2.19 (0.003)
Heart failure1042223.26.03.86 (<0.001)2.69 (<0.001)1845030.76.25.03 (<0.001)3.98 (<0.001)
End-stage renal disease2806.0023.1 (0.002)**10.9 (0.03)**2043.20.56.33 (0.001)3.89 (0.02)
All-cause death1035120.713.51.48 (0.02)1.66 (0.01)1278819.110.61.69 (<0.001)1.35 (0.06)
Combined CHD1425032.513.92.36 (<0.001)2.84 (<0.001)30717554.622.62.44 (<0.001)2.22 (<0.001)
Combined CVD27711069.432.02.18 (<0.001)2.11 (<0.001)510282100.738.02.70 (<0.001)2.42 (<0.001)

Adjusted for age, sex, randomized treatment group, baseline values of BMI, HDL, eGFR, SBP, and DBP, smoking status, diabetes status and history of LVH; **added 1 event into each case and control group to force estimate.

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