Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2013, Article ID 627938, 8 pages
http://dx.doi.org/10.1155/2013/627938
Review Article

Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy

1Rodøvre Centrum 294, 2610 Rodøvre, Denmark
2Shanghai Ruijin Hospital, Shanghai Institute of Hypertension, 197 Ruijin 2nd Road, Shanghai, China
3Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany

Received 16 January 2013; Accepted 20 May 2013

Academic Editor: M. Volpe

Copyright © 2013 Steen Neldam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Ezzati, S. Oza, G. Danaei, and C. J. L. Murray, “Trends and cardiovascular mortality effects of state-level blood pressure and uncontrolled hypertension in the United States,” Circulation, vol. 117, no. 7, pp. 905–914, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Mancia, S. Laurent, E. Agabiti-Rosei et al., “Reappraisal of European guidelines on hypertension management: a European society of hypertension task force document,” Journal of Hypertension, vol. 27, no. 11, pp. 2121–2158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. V. Chobanian, G. L. Bakris, H. R. Black et al., “Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure,” Hypertension, vol. 42, no. 6, pp. 1206–1252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Mancia, B. G. De, A. Dominiczak et al., “Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC),” Journal of Hypertension, vol. 25, no. 6, pp. 1105–1187, 2007. View at Google Scholar
  5. W. C. Cushman, G. W. Evans, R. P. Byington et al., “Effects of intensive blood-pressure control in type 2 diabetes mellitus,” The New England Journal of Medicine, vol. 362, no. 17, pp. 1575–1585, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Denardo, F. H. Messerli, E. Gaxiola et al., “Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST]),” The American Journal of Cardiology, vol. 106, no. 4, pp. 498–503, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Patel, S. MacMahon, J. Chalmers et al., “Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial,” The Lancet, vol. 370, no. 9590, pp. 829–840, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Mancia, “Role of outcome trials in providing information on antihypertensive treatment: importance and limitations,” The American Journal of Hypertension, vol. 19, no. 1, pp. 1–7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Tedesco, F. Natale, and R. Calabrò, “Effects of monotherapy and combination therapy on blood pressure control and target organ damage: a randomized prospective intervention study in a large population of hypertensive patients,” Journal of Clinical Hypertension, vol. 8, no. 9, pp. 634–641, 2006. View at Google Scholar · View at Scopus
  10. D. S. Wald, M. Law, J. K. Morris, J. P. Bestwick, and N. J. Wald, “Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials,” The American Journal of Medicine, vol. 122, no. 3, pp. 290–300, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. H. Gradman, J. N. Basile, B. L. Carter, and G. L. Bakris, “Combination therapy in hypertension,” Journal of Clinical Hypertension, vol. 13, no. 3, pp. 146–154, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. National Institute for Health and Clinical Excellence, “Hypertension: clinical management of primary hypertension in adults,” NICE clinical guidance webpages, 2012, http://guidance.nice.org.uk/CG127.
  13. S. Bangalore and L. Ley, “Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations,” Expert Opinion on Pharmacotherapy, vol. 13, no. 3, pp. 345–355, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. G. L. Bakris, P. A. Sarafidis, M. R. Weir et al., “Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial,” The Lancet, vol. 375, no. 9721, pp. 1173–1181, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Micardis, “Summary of product characteristics,” 2012, http://www.ema.europa.eu/.
  16. S. Yusuf, K. K. Teo, J. Pogue et al., “Telmisartan, ramipril, or both in patients at high risk for vascular events,” The New England Journal of Medicine, vol. 358, no. 15, pp. 1547–1559, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. T. W. Littlejohn III, C. R. Majul, R. Olvera et al., “Results of treatment with telmisartan-amlodipine in hypertensive patients,” Journal of Clinical Hypertension, vol. 11, no. 4, pp. 207–213, 2009. View at Google Scholar
  18. T. W. Littlejohn III, C. R. Majul, R. Olvera et al., “Original research: telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a subgroup analysis of a randomized, placebo-controlled, parallel-group, 4 × 4 factorial study,” Postgraduate Medicine, vol. 121, no. 2, pp. 5–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. R. M. Guthrie, B. Dahlöf, K. A. Jamerson et al., “Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients,” Current Medical Research and Opinion, vol. 27, no. 10, pp. 1995–2008, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Neldam, M. Lang, and R. Jones, “Telmisartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study,” Journal of Clinical Hypertension, vol. 13, no. 7, pp. 459–466, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Neutel, G. Mancia, H. Black et al., “Single-pill combination of telmisartan 80 Mg/Amlodipine 10 Mg provides superior blood pressure reductions in patients with severe hypertension: teamsta severe Htn study: Ht.1.04,” Journal of Hypertension, vol. 28, p. e46, 2010. View at Google Scholar
  22. W. Oigman, M. F. Neves, and R. A. Gismondi, “Combination of telmisartan plus amlodipine in the treatment of hypertension: review of results,” Expert Review of Cardiovascular Therapy, vol. 8, no. 11, pp. 1509–1517, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Sharma, A. Bagchi, S. B. Kinagi, Y. K. Sharma, V. P. Baliga, and C. Bollmall, “Results of a comparative, phase III, 12-week, multicenter, prospective, randomized, double-blind assessment of the efficacy and tolerability of a fixed-dose combination of telmisartan and amlodipine versus amlodipine monotherapy in Indian adults with stage II hypertension,” Clinical Therapeutics, vol. 29, no. 12, pp. 2667–2676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. W. B. White, T. W. Littlejohn, C. R. Majul et al., “Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension,” Blood Pressure Monitoring, vol. 15, no. 4, pp. 205–212, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Neldam, C. Edwards, and R. Jones, “Switching patients with uncontrolled hypertension on amlodipine 10mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study,” Current Medical Research and Opinion, vol. 27, no. 11, pp. 2145–2153, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. “BI Data on file. Study 1235.13,” 2012.
  27. D. Zhu, D. Hu, L. Cheng, and H. Chenglai, “Single-pill combination of telmisartan 80 mg/amlodipine 5 mg provides superior blood pressure reductions on hypertensive patients who fail to respond adequately with amlodipine 5 mg monotherapy.,” ISH Abstract 698.00, vol. 98, supplement 2, 2012. View at Publisher · View at Google Scholar
  28. N. B. Mistry, A. S. Westheim, and S. E. Kjeldsen, “The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials,” Expert Opinion on Pharmacotherapy, vol. 7, no. 5, pp. 575–581, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Quan, K. Chavanu, and J. Merkel, “A review of the efficacy of fixed-dose combinations olmesartan medoxomil/hydrochlorothiazide and amlodipine besylate/benazepril in factorial design studies,” The American Journal of Cardiovascular Drugs, vol. 6, no. 2, pp. 103–113, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. D. A. Sica, “Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats,” Drugs, vol. 62, no. 3, pp. 443–462, 2002. View at Google Scholar · View at Scopus
  31. S. Lewington, R. Clarke, N. Qizilbash, R. Peto, and R. Collins, “Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies,” The Lancet, vol. 360, no. 9349, pp. 1903–1913, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. J. Brown, G. T. McInnes, C. C. Papst, J. Zhang, and T. M. MacDonald, “Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial,” The Lancet, vol. 377, no. 9762, pp. 312–320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Dahlöf, P. S. Sever, N. R. Poulter et al., “Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial,” The Lancet, vol. 366, no. 9489, pp. 895–906, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Julius, S. E. Kjeldsen, M. Weber et al., “Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial,” The Lancet, vol. 363, no. 9426, pp. 2022–2031, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. E. O. Ofili, K. C. Ferdinand, E. Saunders et al., “Irbesartan/HCTZ fixed combinations in patients of different racial/ethnic groups with uncontrolled systolic blood pressure on monotherapy,” Journal of the National Medical Association, vol. 98, no. 4, pp. 618–626, 2006. View at Google Scholar · View at Scopus
  36. M. A. Weber, S. Julius, S. E. Kjeldsen et al., “Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial,” The Lancet, vol. 363, no. 9426, pp. 2049–2051, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Volpe, P. Brommer, U. Haag, and C. Miele, “Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study,” Clinical Drug Investigation, vol. 29, no. 1, pp. 11–25, 2009. View at Publisher · View at Google Scholar · View at Scopus