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International Journal of Hypertension
Volume 2013 (2013), Article ID 749830, 13 pages
http://dx.doi.org/10.1155/2013/749830
Clinical Study

Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors: A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial

1Louisville Metabolic and Atherosclerosis Research Center Inc. (L-MARC), 3288 Illinois Avenue, Louisville, KY 40213, USA
2Shanghai Ruijin Hospital, Shanghai 200025, China
3Boehringer Ingelheim Pharma GmbH & Co. KG, 55216 Ingelheim, Germany
4Hospital 12 de Octubre, 28041 Madrid, Spain

Received 26 November 2012; Accepted 21 February 2013

Academic Editor: M. Volpe

Copyright © 2013 Harold Bays et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. De Marco, G. de Simone, R. Izzo et al., “Classes of antihypertensive medications and blood pressure control in relation to metabolic risk factors,” Journal of Hypertension, vol. 30, no. 1, pp. 188–193, 2012. View at Publisher · View at Google Scholar
  2. S. S. Franklin and J. M. Neutel, “Initial combination therapy for rapid and effective control of moderate and severe hypertension,” Journal of Human Hypertension, vol. 23, no. 1, pp. 4–11, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. H. Gradman, J. N. Basile, B. L. Carter, and G. L. Bakris, “Combination therapy in hypertension,” Journal of the American Society of Hypertension, vol. 4, no. 1, pp. 42–50, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Mancia, G. De Backer, A. Dominiczak et al., “2007 ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension,” Journal of Hypertension, vol. 25, no. 9, pp. 1751–1762, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. V. Chobanian, G. L. Bakris, H. R. Black et al., “Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure,” Hypertension, vol. 42, no. 6, pp. 1206–1252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Maneia, S. Laurent, E. Agabiti-Rosei et al., “Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document,” Journal of Hypertension, vol. 27, no. 11, pp. 2121–2158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Corrao, A. Zambon, A. Parodi et al., “Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy,” Journal of Hypertension, vol. 26, no. 4, pp. 819–824, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. R. E. Schmieder and L. M. Ruilope, “Blood pressure control in patients with comorbidities,” Journal of Clinical Hypertension, vol. 10, no. 8, pp. 624–631, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. P. S. Sever and F. H. Messerli, “Hypertension management 2011: optimal combination therapy,” European Heart Journal, vol. 32, no. 20, pp. 2499–2506, 2011. View at Publisher · View at Google Scholar
  10. S. Yusuf, K. K. Teo, J. Pogue et al., “Telmisartan, ramipril, or both in patients at high risk for vascular events,” The New England Journal of Medicine, vol. 358, no. 15, pp. 1547–1559, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Verdecchia, F. Angeli, G. Gentile, G. Mazzotta, and G. Reboldi, “Telmisartan for the reduction of cardiovascular morbidity and mortality,” Expert Review of Clinical Pharmacology, vol. 4, no. 2, pp. 151–161, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. D. L. Zhu, H. Bays, P. Gao, M. Mattheus, B. Voelker, and L. Ruilope, “Efficacy and tolerability of initial therapy with single-pill combination telmisartan/hydrochlorothiazide 80/25 mg in patients with grade 2 or 3 hypertension: a multinational, randomized, double-blind, active-controlled trial,” Clinical Therapeutics, vol. 34, no. 7, pp. 1613–1624, 2012. View at Google Scholar
  13. National Cholesterol Education Program (NCEP), National Heart Lung and Blood Institute (NHLBI), and National Institutes of Health (NIH), “Detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III),” 2002, http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3full.pdf.
  14. P. W. F. Wilson, R. B. D'Agostino, D. Levy, A. M. Belanger, H. Silbershatz, and W. B. Kannel, “Prediction of coronary heart disease using risk factor categories,” Circulation, vol. 97, no. 18, pp. 1837–1847, 1998. View at Google Scholar · View at Scopus
  15. T. G. Pickering, J. E. Hall, L. J. Appel et al., “Recommendations for blood pressure measurement in humans and experimental animals. Part 1: blood pressure measurement in humans: a statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research,” Hypertension, vol. 45, no. 1, pp. 142–161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. J. M. Neutel, “The role of combination therapy in the management of hypertension,” Nephrology Dialysis Transplantation, vol. 21, no. 6, pp. 1469–1473, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. A. Staessen, J. G. Wang, and L. Thijs, “Cardiovascular protection and blood pressure reduction: a meta-analysis,” The Lancet, vol. 358, no. 9290, pp. 1305–1315, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Mancia, G. De Backer, A. Dominiczak et al., “2007 guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC),” Journal of Hypertension, vol. 25, no. 6, pp. 1105–1187, 2007. View at Publisher · View at Google Scholar · View at Scopus