Statin Improves Flow-Mediated Vasodilation in Chronic Kidney Diseases
Figure 3
Multiple actions of statin on chronic kidney diseases: statin decreases proximal tubular uptake of protein leaked from glomeruli, reducing oxidative stress. Statin also improves podocyte injury, reducing glomerular protein leak. To obtain significant reductions in proteinuria by statin, the decrements in glomerular protein leak must be larger than those of proximal tubular uptake of protein by statin.
