Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening
Figure 2
The IL-2/ complex prevents vascular stiffness induced by Ang II. (a) Aortic stiffness was determined by in vivo measurements of pulse wave velocity with and without immune modulation. (b) Effective wall stiffness (product of Young’s modulus and wall thickness, ) deduced from measured PWV. (c) Wall thickness measured for perfusion fixed aortic specimens that included intimal, medial, and adventitial layers, (). (d) Effective Young’s modulus, . Recordings were made weekly during Ang II treatment. . Data are means ± SEM. vs Day 0 of respective treatment and vs Ang II + PBS at Day 14.
