Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening
Figure 3
Expansion of Tregs with IL-2/ complex impairs Ang II-induced aortic remodeling. Mice were perfusion fixed at Day 14 of Ang II infusion. The lower thoracic aortas were stained with Masson’s Trichrome and PSR for histomorphometric analysis. (a) Representative photomicrographs of PSR stained aortic transverse sections from the treatment groups are shown. (b) The mean aortic medial and (c) adventitial thicknesses were quantified. (d) The mean collagen : lumen ratio was measured by PSR intensity. RT-PCR of extracellular matrix genes procollagen Iα1 (e), procollagen III (f), tropoelastin (g), and the cross-linking enzyme prolysyl oxidase (h) in the aorta are presented. per group. Data are means ± SEM.
