Efficacy and Tolerability of Telmisartan Plus Amlodipine in Asian Patients Not Adequately Controlled on Either Monotherapy or on Low-Dose Combination Therapy
Table 2
Demographics and baseline characteristics (full analysis set).
Nonresponders to A5
Nonresponders to T40 or T80
Nonresponders to low-dose T/A
Total
A5 ()
T40/A5 SPC ()
T80/A5 SPC ()
T40 ()
T40/A5 SPC ()
T80 ()
T80/A5 SPC ()
T40/A5 SPC ()
T80/A5 SPC ()
Age, mean (SD)
54.6 (10.0)
57.0 (9.6)
52.4 (8.7)
55.5 (10.2)
55.6 (9.1)
54.8 (8.7)
54.5 (9.0)
52.8 (9.4)
54.6 (8.4)
54.9 (9.5)
Age group, (%)
<50 years
124 (29.8)
63 (24.0)
60 (38.7)
43 (27.2)
35 (22.9)
24 (27.9)
28 (32.2)
45 (40.2)
35 (31.3)
457 (29.6)
50–<60 years
159 (38.2)
100 (38.0)
65 (41.9)
62 (39.2)
66 (43.1)
34 (39.5)
31 (35.6)
40 (35.7)
49 (43.8)
606 (39.3)
≥60 years
133 (32.0)
100 (38.0)
30 (19.4)
53 (33.5)
52 (34.0)
28 (32.6)
28 (32.2)
27 (24.1)
28 (25.0)
479 (31.1)
BMI, mean (SD)
25.7 (3.9)
25.5 (3.2)
26.1 (3.1)
25.7 (4.0)
25.3 (3.6)
26.4 (4.1)
25.6 (4.0)
26.2 (4.0)
26.1 (4.2)
25.8 (3.7)
Sex, (%)
Female
147 (35.3)
71 (27.0)
78 (50.3)
35 (22.2)
42 (27.5)
12 (14.0)
20 (23.0)
24 (21.4)
23 (20.5)
452 (29.3)
Male
269 (64.7)
192 (73.0)
77 (49.7)
123 (77.8)
111 (72.5)
74 (86.0)
67 (77.0)
88 (78.6)
89 (79.5)
1090 (70.7)
Race, (%)
Asian
416 (100.0)
263 (100.0)
155 (100.0)
158 (100)
153 (100)
86 (100)
87 (100)
112 (100)
112 (100)
1542 (100)
Diabetes
No
357 (85.8)
213 (81.0)
137 (88.4)
147 (93.0)
141 (92.2)
77 (89.5)
80 (92.0)
105 (93.8)
105 (93.8)
1362 (88.3)
Yes
59 (14.2)
50 (19.0)
18 (11.6)
11 (7.0)
12 (7.8)
9 (10.5)
7 (8.0)
7 (6.3)
7 (6.3)
180 (11.7)
Mean (SD) baseline SBP, mm Hg
145.7 (10.7)
144.6 (11.8)
146.4 (12.2)
144.8 (13.4)
145.7 (12.2)
144.3 (14.5)
143.7 (13.8)
134.5 (13.6)
133.7 (10.6)
143.6 (12.7)
Mean (SD) baseline DBP, mm Hg
96.5 (5.6)
95.9 (5.0)
97.2 (5.5)
96.6 (6.0)
96.8 (5.3)
98.5 (6.7)
98.0 (6.0)
90.7 (8.0)
90.1 (6.7)
95.8 (6.3)
Baseline PR, mean (SD)
71.4 (9.4)
70.6 (8.8)
70.7 (7.6)
69.1 (8.5)
68.8 (7.7)
71.2 (9.8)
68.1 (8.3)
71.1 (9.8)
71.7 (9.3)
70.5 (8.9)
Disease duration, mean (SD)
7.5 (8.0)
6.8 (7.8)
7.7 (8.9)
7.1 (7.5)
7.8 (7.7)
8.6 (6.1)
8.3 (6.4)
7.8 (7.6)
6.6 (6.8)
7.5 (8.0)
A5: amlodipine 5 mg; BMI: body mass index; DBP: diastolic blood pressure; PR: pulse rate; SBP: systolic blood pressure; SD: standard deviation; SPC: single-pill combination; T40: telmisartan 40 mg; T80: telmisartan 80 mg; T/A: telmisartan plus amlodipine. The number of patients included in this analysis may differ from those of the individual study publications, due to differences in statistical approach for the individual studies.
