The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility

Table 1

Baseline characteristics of two study populations.

Baseline characteristics	EH patients	Controls	values
Discovery cohort (Kursk region): 1 362 EH patients and 843 healthy subjects
Age, mean ± standard deviation	56.4 ± 10.4	55.8 ± 8.8	0.18
Gender; (M-male, F-female)	711 M (52.2%); 651 F (47.8%)	406 M (48.2%); 437 F (51.8%)	0.07
Body mass index; (kg/m^2), mean ± standard deviation	27.3 ± 6.5	26.2 ± 5.9
Family history; of hypertension	Yes 764 (65.9%); No 395 (34.1%)	Yes 414 (57.8%); No 302 (42.2%)
Smoking status	Yes 841 (67.4%); No 406 (32.6%)	Yes 483 (61.9%); No 297 (38.1%)
Replication cohort (Belgorod region): 357 EH patients and 422 population controls
Age, mean ± standard deviation	58.4 ± 9.5	57.3 ± 10.2	0.12
Gender; (M-male, F-female)	211 M (59.1%); 146 F (40.9%)	267 M (63.3%); 155 F (36.7%)	0.23
Body mass index; (kg/m^2), mean ± standard deviation	26.2 ± 4.8	25.6 ± 3.9	0.07
Family history; of hypertension	NA	NA	—
Smoking status	NA	NA	—

*Means a significant difference between the groups.