Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
Figure 1
Pressure-diameter relationship determined in mesenteric resistance arteries isolated from normotensive rats (WKY: (a)) or spontaneously hypertensive rats (SHRs: (b)) submitted to arterial ligation for 1, 3, 8, or 24 weeks. Ligated arteries were designated as low-flow (LF) arteries. The artery located between two ligated vessels was designated as a high-flow (HF) artery. Other arteries had a normal flow (NF). Changes in diameter (C) due to remodeling in HF (positive values) and LF arteries (negative values) were calculated from the data shown in (a) and (b) and expressed as percentage change in diameter compared to NF vessels. Values representing mean ± SEM are shown ( rats per group). , HF or LF versus NF arteries. , SHRs versus WKY, rats within equivalent arteries (NF, LF, or HF).
