Quantifying Proteinuria in Hypertensive Disorders of Pregnancy

Table 7

Reported cutoff values for UPCR and diagnostic summary in pregnant women with hypertensive disorders.

Study	UPCR	Protein estimation method	Sensitivity (%)	Specificity (%)	Area under receiver operating curve (95% CI)	Positive likelihood ratio	Negative likelihood ratio
Rodriguez-Thompson and Lieberman 2001 [12]	0.19	Pyrogallol red reaction	90	70	0.91 (0.87 to 0.96)	3	0.14
Durnwald and Mercer 2003 [13]	0.39	Biuret method	72.6	73.1	0.8	2.7	0.37
Al et al. 2004 [14]	0.19	Trichloroacetic acid	85	73	0.86 (0.80 to 0.93)	3.15	0.21
Yamasmit et al. 2004 [15]	0.25	Pyrogallol red reaction	96.6	92.3	0.93	12.55	0.04
Taherian et al. 2006 [16]	0.18	Trichloroacetic acid	86.3	100	0.94 (0.88 to 0.98)	#	0.14
Leaños-Miranda et al. 2007 [17]	0.30	Bradford method	98.2	98.8	*	81.8	0.02
Wheeler et al. 2007 [18]	0.21	Biuret method	86.8	77.6	0.82	3.88	0.17
Aggarwal et al. 2008 [10]	1.14	Biuret method	72	75	*	2.88	0.37
Shaikh et al. 2010 [19]	0.20	Biuret method	91.2	87.8	0.84	7.47	0.10
Dwyer et al. 2008 [5]	0.28	Pyrogallol red reaction	65	95	0.83 (0.76–0.88)	13	0.36
Kyle et al. 2008 [20]	0.27	Polyethylene glycol turbidimetry	92.3	97.1	*	31.82	0.07
Eslamian et al. 2011 [21]	0.22	Turbidimetric method	87	92.6	0.93 (0.85–0.99)	11.76	0.14
Kumari et al. 2013 [22]	0.30	Coomassie reagent method	90	84	0.83	5.65	0.12
Gaddy-Dubac et al. 2013 [23]	0.30	Not mentioned	32.9	85	0.74 (0.67–0.82)	2.19	0.79
Sharma et al. 2013 [24]	0.25	Biuret method	69	75	0.79 (0.66–0.92)	2.76	0.41
Park et al. 2013 [11]	0.63	Pyrogallol red reaction	87.1	100	0.956 (0.90–1.00)	#	0.13
Present study 2014	0.45	Benzethonium method	82.1	87.5	0.89 (0.83–0.95)	6.56	0.21

not calculated in the study.
indicates very high values, but cannot be calculated because of empty cell in 2 × 2 table.