Modulation of miRNAs in Pulmonary Hypertension

Table 1

Vascular smooth muscle cells and miRNA modulation.

miRNA	Function	Target gene(s)	Reference
miR-1	Promote VSMC differentiation	Myocardin, KLF4	[26, 27]
miR-21	Promote VSMC differentiation	PDCD4	[28]
miR-24	VSMC proliferation and repression of contractile gene expression	Tribbles-like protein 3, SMURF1	[29]
miR-26a	Promote VSMC dedifferentiation	Smad1 and Smad4	[30]
miR-143/145	Promote VSMC differentiation	KLF4, KLF5, ELK1, versican, BMP4, MRTF	[31–33]
miR-146	Promote VSMC dedifferentiation and proliferation	KLF4	[34]
miR-221/222	Promote VSMC dedifferentiation and proliferation	p27Kip, c-kit	[35, 36]