International Journal of Hypertension / 2015 / Article / Tab 2

Research Article

CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence

Table 2

Associations of the CYP17A1 locus (rs10786718#) and studied BP phenotypes.

MalesFemales
 Beta (SE)AAGAGG value Beta (SE)GGGAAA value
Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)

(A) SBP
 Reactivity to standing−0.17 (0.70)8.5 (1.5)11.8 (0.8)10.1 (0.6)0.810.92 (0.66)9.5 (0.5)9.4 (0.7)7.6 (1.4)0.16
 Poststanding resting*0.12 (0.98)120.9 (2.0)125.7 (1.0)123.5 (0.8)0.90−0.17 (0.85)118.7 (0.7)119.8 (0.9)117.9 (1.9)0.85
 Reactivity to math3.40 (0.76)12.4 (1.6)17.3 (0.8)20.0 (0.6)8.3E − 060.48 (0.75)16.5 (0.6)16.8 (0.8)14.4 (1.6)0.52
 Postmath resting*0.38 (0.95)125.6 (2.0)129.1 (1.0)127.8 (0.8)0.690.31 (0.90)124.0 (0.7)123.9 (1.0)123.6 (2.0)0.73
(B) DBP
 Reactivity to standing*0.09 (0.42)9.2 (0.9)10.5 (0.5)10.1 (0.4)0.830.23 (0.42)10.4 (0.4)10.5 (0.5)9.3 (0.9)0.58
 Poststanding resting−0.07 (0.68)77.3 (1.5)80.6 (0.7)78.9 (0.6)0.920.44 (0.65)75.3 (0.5)76.5 (0.7)72.5 (1.4)0.50
 Reactivity to math*1.85 (0.42)6.6 (0.9)10.5 (0.4)11.4 (0.4)1.1E − 050.24 (0.42)10.5 (0.4)10.5 (0.5)9.4 (0.9)0.57
 Postmath resting0.03 (0.69)80.6 (1.5)83.0 (0.7)81.9 (0.6)0.970.30 (0.66)79.3 (0.5)79.7 (0.7)77.8 (1.5)0.65

Beta (SE = standard error) is the effect size on BP in mm Hg, per 1 copy of the index allele (G) based on an additive model adjusted for age and height.
*Model was additionally adjusted for initial BP.
#Minor allele (A) frequencies in males and females are 0.27 and 0.26, respectively.