Research Article
Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa
Table 2
Frequencies of renin-angiotensin system genes polymorphisms (cases versus controls).
| | Polymorphisms | Controls | Cases | OR | 95% CI | value |
| | Total | 204 | 202 | | | | | AGT 235M/T | | | | | | | TT versus MT + MM, (%) | 177 (86.76) | 171 (84.65) | 0.84 | 0.46–1.53 | 0.57 | | MT versus TT + MM, (%) | 24 (11.77) | 29 (14.36) | 1.26 | 0.68–2.35 | 0.46 | | MM versus TT + MT, (%) | 3 (1.47) | 2 (0.99) | 0.67 | 0.06–5.92 | 1 | | T versus M, (%) | 378 (0.93) | 371 (0.92) | 0.89 | 0.51–1.54 | 0.70 | | HWE value | 0.15 | 0.83 | | | | | ACE I/D | | | | | | | DD versus ID + II, (%) | 73 (35.78) | 135 (66.83) | 3.62 | 2.35–5.56 | <0.00001 | | ID versus II + DD, (%) | 104 (50.98) | 57 (28.22) | 0.38 | 0.25–0.58 | <0.00001 | | II versus DD + ID, (%) | 27 (13.24) | 10 (4.95) | 0.34 | 0.14–0.76 | 0.005 | | D versus I, (%) | 250 (0.61) | 327 (0.81) | 2.68 | 1.93–3.74 | <0.00001 | | HWE value | 0.57 | 0.48 | | | | | AT1R 1166 A/C | | | | | | | CC versus AC + AA, (%) | 0 (0.00) | 0 (0.00) | 0 | 0–4.21 | 0.19 | | AC versus AA + CC, (%) | 7 (3.43) | 7 (3.47) | 1.01 | 0.30–3.44 | 1.00 | | AA versus CC + AC, (%) | 197 (96.57) | 195 (96.53) | 0.99 | 0.29–3.38 | 1.00 | | C versus A, (%) | 7 (0.02) | 7 (0.02) | 1.01 | 0.30–3.41 | 1.00 | | HWE value | 0.97 | 0.97 | | | |
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OR: odds ratio; CI: confidence intervals; HWE: Hardy-Weinberg equilibrium; AGT: angiotensinogen; ACE: angiotensin converting enzyme; AT1R: angiotensin II type 1 receptor.
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